No, it will not. This one is specifically for the PDP 2.0 cut found on Walther PDPs. The one C&H makes for the Sig P320 should work with a DPP footprint plate if you really want this optic. Honestly, if it were me, I’d be taking a hard look at the new Vortex Venom enclosed optic for your application. It’s cheaper and also uses the DPP footprint. The Vortex Defender line is also a good option if you have it in the budget, but the new Venom enclosed is definitely adequate if you want to save a little bit.