Yes, the SIG SAUER Sierra3BDX 5x20mm Rifle Scope Combo Kit 30mm Tube can be used with a 45-70 chambered lever action. Just ensure that it is mounted securely.
There is not a specific ballistic setting for 450 Bushmaster with the SIG SAUER Sierra3BDX 5x20mm Rifle Scope Combo Kit 30mm Tube.
Yes. The Sig Sauer Sierra3BDX 5x20mm Rifle Scope Combo Kit can be used with the AR15 and AR10 platform. When using the SIG BDX app, it will provide ballistic information and calculations for your specific caliber and rifle.
The Sig Sauer Sierra3BDX 5x20mm Rifle Scope uses a 30mm maintube. I would recommend using a dedicated AR15 scope mount. Trying to co-witness this scope with iron sights would not work because the scope will un-focus your front sight. Using an AR15 scope mount like the Aero Precision Ultralight 30mm Scope Mount (linked below) would be my recommendation.
https://www.opticsplanet.com/aero-precision-ultralight-30mm-scope-mount-spr.html