It's different per rifle. The barrel length, twist rate, bullet design, bullet weight, powder type, amount of powder, etc. No scope is ever for one cartridge unless you get into specialized military scopes - they use the exact same ammo per weapon system. You can learn the ballistics of any scope with any ammo. It just takes a little testing. On some of their models, Leupold will send you a (CDS) custom dial once you figure out your ballistics.