Yes, both sides of the handle can be pulled to actuate the latch opening making it ambidextrous. The gas ports on top of the stem do point out to the right, but we have had several lefty shooters still choose our charging handles because they still reduce gas in the face even with having some gas relief ported out to the right. There are enough gas blocking features throughout the design that it still can help lefty shooters. But of course that does depend on the rifle, ammunition, and personal preferrence.