Yes, it will work in a standard Sig 516, it does not come with anti-walk pins and Rise Armament recommends using KNS Anti-Walk Pins and those can be found here:
https://www.opticsplanet.com/kns-precision-ar15-m16-154-diameter-gen-2-mod-2-non-rotate-trigger-hammer-pins.html
It will also work in ANY AR platform that accepts aftermarket triggers and that includes AR's chambered in .300 Blackout.
The 516 comes with anti rotation/walk pins from the factory already installed.
I have this trigger pack installed in my 516 SBR and used the factory pins with it.