No it will not work.
According to sharps rifle company it fits standard AR-15/M16/M4 rifles chambered in .223/5.56, Sharps 25-45, and 300 Blackout calibers ....
300blk shares the same casings as the 5.56/2.23. it will work on a 300blk, as does every other 5.56 BCG
yes it will work with 300 blackout
Yes, this bolt WILL work with .300BO/.300AAC.
I have about 400 rounds through my DDM4 .300BO upper without any issues. About 100 rounds were with steel-case and, still, no issues.