These are the specifications provided by ATI:
Accepts standard mil-spec parts
Multi-Caliber: 5.56mm, 300BLK, 22LR, 6.8 SPC and others
Material: Polymer w/Insert
Patented Metal-reinforced polymer upper receiver
Lightweight with durability of a forged aluminum upper
Metal insert to reinforce critical areas of the upper
Only 1/2 a pound! (7 ounces)
As you can see they do list most calibers that can be used in an AR-15 upper.