This will most likely not accommodate a 10/22 take down with an optic. The optic would have to be very low to receiver to even think about squeezing into the receiver compartment. This is made specifically designed for side-by-side, over/under or pump/auto take down firearms. You could use some sort of quick detach mount for the scope and just remove it when you are storing it. If you want a different recommendation please email us at techsales@opticsplanet.com and we can provide some more recommendations.